The personalized development of temporary polymer matrices with minimal inflammatory issues that would allow cell colonization within their architecture during degradation and trigger the formation of the target tissue The main challenge of tissue engineering is to overcome the problems associated with organ shortage by providing surgeons with functional substitutes developed in vitro. In addition, the low availability of donor organs is no longer in line with the ever-increasing demand for tissues. Currently, tissue repair is performed either by autologous grafts or by transplantation from deceased donors causing problems related to immune rejection. The aging of the population leads to a growing need for new tissue repair technologies to substitute defect organs. Innovation lies both on the preparation of individualized implants with complex geometry fostering cell colonization and tissue integration and the formulation of new biocompatible shape-memory polymers minimizing mechanical trauma and immune rejection during and after the implantation. Since the first prosthesis printed in 1999 or the first blood vessel in 2010, the range of applications enabled by this technology in combination with polymers is promising.ģD4MED’s objective is to develop innovative 3D matrices for tissue engineering in order to rebuild, regenerate or replace the function of defective tissues or organs. Development of personalized 3D implants in new shape-memory polymer materials to improve patient careĪfter many years of technological development, 3D printing has shown its usefulness in the tissue engineering sector.
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